Regulación epigenética de teluro (Te) y selenio (Se) en los mecanismos determinantes de la expresión emocional en la rata
Cell homeostasis is regulated by complex mechanisms. One of these mechanisms is modulation of gene expression by epigenesis, process known to be one of the most important factors in the regulation of gene expression. Previously in our laboratory, children coming from a determined geographical region...
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| Autores principales: | , , , |
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| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=14266 |
| Sumario: | Cell homeostasis is regulated by complex mechanisms. One of these mechanisms is modulation of gene expression by epigenesis, process known to be one of the most important factors in the regulation of gene expression. Previously in our laboratory, children coming from a determined geographical region, rich in metal and non-metal deposits in La Rioja province, Argentine, presented phenotypic alterations of the HSR gene expression. This gene locus has been associated to handedness, brain asymmetry, writing-reading capacities, and susceptibility to develop schizophrenia. Molecular analysis of methylation patterns of DNA in the blood of these children showed alterations when compared to control children from other region. Since one of the mechanisms of epigenesis is regulation of methylation of DNA, hypothesis that the epigenetic influence on HSR is mediated by environmental factors such as the presence of trace elements was considered.In subsequent experiments in rats subjected to a chronic regimen of Te ingestion in drinking water at the same concentration of that found in water and soils of La Rioja, changes in behaviours equivalent to that found in humans and alteration of the methylation DNA patterns were found. The most outstanding finding was that altered methylation patterns of DNA in the hippocampus structure and not in the prefrontal cortex of Te-treated animals. Possibility that Te could interferes with other essential element, was considered in the previous research project. Then, the interaction of Se with Te was studied, and experiments showed that Se was able to counteract almost all effects induced by the Te treatment, suggesting that Te might be swapping with Se. The principal affected behaviours were social interaction, lateralized exploration and survival responses. It is known that exploration is an important response of cognition, and cognition is modulated by emotional neural circuits. Possibility that trace elements might be affecting primarily these emotional neural mechanisms, and consequently cognition expression is modified has not been studied.The objective of the present study is to evaluate if Se, Te, and Te-Se interaction has a modulating role on emotionality, and if the interaction with Te could also affect these primary processes. |
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