Epigenética
Epigenetics as a science, adopts the definition of being the study of inheritable changes in the regulation of the activity and expression of genes by the action of external factors, which are not dependent on the DNA sequence, that is, they do not originate modifications in the order of the sequenc...
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2020
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| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=15943 |
| Sumario: | Epigenetics as a science, adopts the definition of being the study of inheritable changes in the regulation of the activity and expression of genes by the action of external factors, which are not dependent on the DNA sequence, that is, they do not originate modifications in the order of the sequence of the nitrogenous bases of DNA.
The main work of this science is to clarify how, when and why gene expression is regulated, and how the environment influences this expression.
he epigenome is mostly vulnerable to various environmental factors during embryogenesis because DNA synthesis during this period is very high, and the DNA methylation patterns required for the development of normal tissues are established during this stage of intense development. Epigenetic modifications caused by the nutritional environment of the embryo and by the external environment that surrounds its mother, are involved in the etiology of diseases and malformations, being the great difference with genetics, epigenetics is a reversible process, because the Intervening mechanisms are regulated by enzymes.
Human growth and development implies a complex, dynamic and continuous process, which originates from a single cell, which, through different actions of division, migration, differentiation, reorganization and programmed death, will culminate in the formation of a whole human being. Throughout this process the different systems and organs develop, taking place the maxillofacial development during the first weeks of gestation, period of greater sensitivity to the action of extrinsic factors, and as a consequence, to the appearance of congenital malformations. |
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