La estimulación gabaérgica del núcleo septal lateral del cerebro de ratas macho incrementa la respuesta agresiva frente a estímulos neutros
Destruction of lateral septum –a nucleus located in subcortical regions of the anterior brain– has been related to an entity known as rage septal syndrome. In the present paper we demonstrate that the direct GABAergic agonist muscimol produces “fear inhibition” when tested at non-sedative doses i...
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| Publicado en: | Revista Médica Universitaria |
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| Autores principales: | , , , , , , , , |
| Materias: | |
| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=3840 |
| Sumario: | Destruction of lateral septum –a nucleus located in subcortical regions of the anterior
brain– has been related to an entity known as rage septal syndrome. In the present
paper we demonstrate that the direct GABAergic agonist muscimol produces “fear
inhibition” when tested at non-sedative doses in Sprague-Dawley male rats. This
phenomenon is also supported by an increase of aggressive behaviors directed to
otherwise neutral objects. Since the septal lateral has been involved in several
psychiatric diseases, it appears as potentially interesting to contribute to the
knowledge of its function by taking advantage of eventual modulators known to be
present in the nucleus.
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