Desarrollo de lesiones displásicas y neoplásicas linguales en animales de laboratorio
Experimental models play an important role in biomedical sciences in elucidating the pathogenesis of different disorders that affect living organisms, including humans, and are also useful for: studying the molecular basis involved in any disease, in development of diagnostic markers and in eva...
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| Publicado en: | Revista de la Facultad de Odontología |
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| Autores principales: | , , |
| Materias: | |
| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=7319 |
| Sumario: | Experimental models play an important role in biomedical
sciences in elucidating the pathogenesis of different
disorders that affect living organisms, including humans,
and are also useful for: studying the molecular basis involved
in any disease, in development of diagnostic markers
and in evaluating the efficacy and safety of different
treatment options, including potential drug therapies.
There are general factors and those that are specific to
the oral environment, leading to the development and
progression of neoplastic lesions of the oral cavity, accordingly,
make this project whose main objective is to
develop an experimental model of oral cancer in rats.
Materials and methods: we used 4-(4-nitroquinoline-
1-oxide) to induce tumors in the oral mucosa in rats
according to previously established protocols.
Results: The first clinically suspicious lesions developed at
3 months into the experiment, the tissue was removed
and fixed samples, processed and examined by light microscopy.
The samples showed patterns consistent with
intraepithelial dysplasia and squamous cell carcinoma. It
hopes to develop an experimental model as a basis for
further study of basic and clinical application. |
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