Respuestas fisiológicas frente al estrés asociado a situaciones hipometabólicas en un organismo modelo emergente
Animals use different adaptive strategies to tolerate harsh environmental conditions like changes in temperature, humidity, availability of water, food, salinity, oxygen concentration or UV radiation. A widely studied physiological response strategy has been called "Preparation for oxidative st...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Publicado: |
2019
|
| Materias: | |
| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=14429 |
| Sumario: | Animals use different adaptive strategies to tolerate harsh environmental conditions like changes in temperature, humidity, availability of water, food, salinity, oxygen concentration or UV radiation. A widely studied physiological response strategy has been called "Preparation for oxidative stress" (POS). This strategy, observed in different animal phyla, implies that during hypometabolic states (i.e. hibernation, estivation, hypoxia, etc), animals activate mechanisms of anticipated protection against oxidative stress, which will act upon re-oxygenation and cellular reactivation, during the increase of their metabolic rate. Our research group has contributed scientifically to the study of the metabolism and internal environment of the emerging model organism Pomacea canaliculata, as well as to the characterization of quiescence experimental models (estivation and hibernation) and the identification of the mechanisms that allow its tolerance to oxidative stress induced by prolonged activity-quiescence cycles. Related to these two hypometabolic states, we have shown that this organism uses POS strategy to tolerate the arousal from a long quiescence. It is interesting to note that this species uses non-enzymatic antioxidants as the main defense after prolonged periods of estivation. Is interesting to evaluate the physiological response of this species in early stages of the activity-estivation cycle, because of at this time the molecular phenomena probably occur as a response to the first increase in free radicals. Therefore, we propose the following study objectives: a) to demonstrate at tissue level the physiological responses to oxidative stress, developed during a short period of hypometabolism, induced by cycles of activity-estivation; b) study changes in the internal milieu that reflect homeostatic responses to hypometabolic stress. The characterization of this experimental model and the physiological defense strategies used by this species against hypometabolic situations can lead to practical and translational applications, such as its use in organ transplantation or in pathologies that present tissue hypoxia. |
|---|
