Bacteriemias por Pseudomonas Aeruginosa
Objectives: To assess the clinical features and morbimortality of Pseudomonas aeruginosa bacteremia compared to Klebsiella spp bacteremia occurred in hospitalized adult patients of an Internal Medicine service.- Material and methods: Protocolized, descriptive and observational study performed in...
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| Publicado en: | Revista Médica Universitaria |
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| Autores principales: | , , , , , |
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| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=3841 |
| descriptores_str_mv |
Datos estadísticos Klebsiella Mendoza (Argentina) Pacientes hospitalizados Pseudomonos aeruginosa Servicio de Clínica Médica |
|---|---|
| todos_str_mv |
1221 3836 HLL HLL_SI HospLagClinMed HospLagClinMed spa UNCuyo FCM Dto. Medicina Interna UNCuyo FCM Dto. Medicina Interna |
| titulo_str_mv |
Bacteriemias por Pseudomonas Aeruginosa |
| autor_str_mv |
Carena, José Alberto De Schutter, Emiliano Lloret, L. Mosso, Marcelo Orlando, Juan Salomón, Susana Elsa |
| disciplina_str_mv |
Ciencias médicas |
| description_str_mv |
Objectives: To assess the clinical features and morbimortality of Pseudomonas
aeruginosa bacteremia compared to Klebsiella spp bacteremia occurred in hospitalized
adult patients of an Internal Medicine service.-
Material and methods: Protocolized, descriptive and observational study performed in a 20
years period. Inclusion criteria: 2 o more positive blood cultures. Data was analized with
Epi Info 6.04 and the criteria of statistically significance was p<0.05.
Results: 282 gram negative bacili bacteremia were found in the study period. 19 were
caused by P.aeruginosa (6.7%) and 76 by Klebsiella (26.9%). No significant differences
were found on average age [53.9 years(DS±17.9 ) vs 58.7 years (DS±15.2)], sex (female
26.3 vs 38.2%) and complications (77.8 vs 77.3%). Neutropenia (52.6 vs
9.2%)(p<0.0001), major comorbidity (94.7 vs 68.4%)(p<0.05), neoplasms (47.4 vs
22.4%)(p<0.05), use of corticosteroids (21.1 vs 3.9%)(p<0.05), immunosupressive drugs
(31.6 vs 7.9%)(p<0.01), thrombocytopenia (77.7 vs 49.3%) (p<0.05) and leukopenia (52.6
vs 21.3%)(p<0.01) were found in a higher frequency among P.aerugionsa bacteremia.
Hypoalbuminemia was more common in Klebsiella spp group (88.5 vs 37.5%)(p<0.001).
No significant differences were found between source of infection (78.9 vs 77.6%), anemia
(84.2 vs 71.2%), infectious complications (84.2 vs 73.7%), descompensation of comorbid
condition (55.6 vs 51.3%) and encephalopathy (36.8 vs 57.9%)(pNS). Mortality within 7
days of admision was significantly higher in P.aeruginosa bacteremia (57.1 vs 12%)
(p<0.01), without differences in crude mortality (36.8 vs 32.9%) (pNS).
Conclusions: P.aeruginosa bacteremia compared to Klebsiella spp. bacteremia were
significantly associated to a higher frequency of neoplasms, leukopenia, thrombocytopenia
and neutropenia, major comorbidity, use of corticosteroids and immunosupressive drug
and mortality within 7 days.
Objetivos: Analizar características clínicas y morbimortalidad de las bacteriemias por Pseudomonas aeruginosa comparadas con Klebsiella spp en pacientes hospitalizados en un Servicio de Clínica Médica de adultos. Material y métodos: Estudio protocolizado, descriptivo, observacional de 15 años de duración. Criterio de inclusión: 2 o más hemocultivos positivos para el germen. Los datos fueron procesados en EPI Info 6.04. El criterio de significación se estableció para un error alfa menor del 5%. Resultados: Se detectaron en el período de estudio 282 bacteriemias por bacilos gram negativos de las cuales 19 fueron por Pseudomonas aeruginosa (6.7%) y 76 por Klebsiella (26.9%). No se encontraron diferencias significativas entre ambas en cuanto a edad media [53.9 años (DS±17.9 ) vs 58.7 años (DS±15.2)], sexo (femenino: 26.3 vs 38.2%) ni complicaciones (77.8 vs 77.3%). La presencia de neutropenia (52.6 vs 9.2%)(p<0.0001), comorbilidad mayor (94.7 vs 68.4%)(p<0.05), neoplasias (47.4 vs 22.4%)(p<0.05), uso de corticoides (21.1 vs 3.9%)(p<0.05), e inmunosupresores (31.6 vs 7.9%)(p<0.01), trombocitopenia (77.7 vs 49.3%) (p<0.05) y leucopenia (52.6 vs 21.3%)(p<0.01) fueron más frecuentes en las bacteriemias por P. aeruginosa. Resultó más frecuente la hipoalbuminemia (88.5 vs 37.5%)(p<0.001) en las bacteriemias por Klebsiella spp. No se encontraron diferencias significativas en cuanto a puerta de entrada conocida (78.9 vs 77.6%), anemia (84.2 vs 71.2%), complicaciones infecciosas (84.2 vs 73.7%), descompensación de comórbidas (55.6 vs 51.3%) y encefalopatía (36.8 vs 57.9%)(pNS). La mortalidad precoz (dentro de los 7 días) fue significativamente mayor en el grupo de las bacteriemias por P.aeruginosa (57.1 vs 12%) (p<0.01), sin diferencias en la mortalidad global (36.8 vs 32.9%) (pNS). Conclusiones: Las bacteriemias por P.aeruginosa comparadas con las producidas por Klebsiella spp. se asociaron significativamente a mayor frecuencia de neoplasias, leucopenia, trombocitopenia y neutropenia, comorbilidad mayor, uso de corticoides e inmunosupresores, y a mortalidad precoz. |
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Textual: Revistas |
| id |
3841 |
| plantilla_str |
Artículo de Revista |
| record_format |
article |
| container_title |
Revista Médica Universitaria |
| journal_title_str |
Revista Médica Universitaria |
| journal_id_str |
r-1221 |
| container_issue |
Revista Médica Universitaria |
| container_volume |
Vol. 5, no. 1 |
| journal_issue_str |
Vol. 5, no. 1 |
| tipo_str |
textuales |
| type_str_mv |
Articulos |
| title_full |
Bacteriemias por Pseudomonas Aeruginosa |
| title_fullStr |
Bacteriemias por Pseudomonas Aeruginosa Bacteriemias por Pseudomonas Aeruginosa |
| title_full_unstemmed |
Bacteriemias por Pseudomonas Aeruginosa Bacteriemias por Pseudomonas Aeruginosa |
| description |
Objectives: To assess the clinical features and morbimortality of Pseudomonas
aeruginosa bacteremia compared to Klebsiella spp bacteremia occurred in hospitalized
adult patients of an Internal Medicine service.-
Material and methods: Protocolized, descriptive and observational study performed in a 20
years period. Inclusion criteria: 2 o more positive blood cultures. Data was analized with
Epi Info 6.04 and the criteria of statistically significance was p<0.05.
Results: 282 gram negative bacili bacteremia were found in the study period. 19 were
caused by P.aeruginosa (6.7%) and 76 by Klebsiella (26.9%). No significant differences
were found on average age [53.9 years(DS±17.9 ) vs 58.7 years (DS±15.2)], sex (female
26.3 vs 38.2%) and complications (77.8 vs 77.3%). Neutropenia (52.6 vs
9.2%)(p<0.0001), major comorbidity (94.7 vs 68.4%)(p<0.05), neoplasms (47.4 vs
22.4%)(p<0.05), use of corticosteroids (21.1 vs 3.9%)(p<0.05), immunosupressive drugs
(31.6 vs 7.9%)(p<0.01), thrombocytopenia (77.7 vs 49.3%) (p<0.05) and leukopenia (52.6
vs 21.3%)(p<0.01) were found in a higher frequency among P.aerugionsa bacteremia.
Hypoalbuminemia was more common in Klebsiella spp group (88.5 vs 37.5%)(p<0.001).
No significant differences were found between source of infection (78.9 vs 77.6%), anemia
(84.2 vs 71.2%), infectious complications (84.2 vs 73.7%), descompensation of comorbid
condition (55.6 vs 51.3%) and encephalopathy (36.8 vs 57.9%)(pNS). Mortality within 7
days of admision was significantly higher in P.aeruginosa bacteremia (57.1 vs 12%)
(p<0.01), without differences in crude mortality (36.8 vs 32.9%) (pNS).
Conclusions: P.aeruginosa bacteremia compared to Klebsiella spp. bacteremia were
significantly associated to a higher frequency of neoplasms, leukopenia, thrombocytopenia
and neutropenia, major comorbidity, use of corticosteroids and immunosupressive drug
and mortality within 7 days.
|
| dependencia_str_mv |
Facultad de Ciencias Médicas |
| title |
Bacteriemias por Pseudomonas Aeruginosa |
| spellingShingle |
Bacteriemias por Pseudomonas Aeruginosa Datos estadísticos Klebsiella Mendoza (Argentina) Pacientes hospitalizados Pseudomonos aeruginosa Servicio de Clínica Médica Carena, José Alberto De Schutter, Emiliano Lloret, L. Mosso, Marcelo Orlando, Juan Salomón, Susana Elsa |
| topic |
Datos estadísticos Klebsiella Mendoza (Argentina) Pacientes hospitalizados Pseudomonos aeruginosa Servicio de Clínica Médica |
| topic_facet |
Datos estadísticos Klebsiella Mendoza (Argentina) Pacientes hospitalizados Pseudomonos aeruginosa Servicio de Clínica Médica |
| author |
Carena, José Alberto De Schutter, Emiliano Lloret, L. Mosso, Marcelo Orlando, Juan Salomón, Susana Elsa |
| author_facet |
Carena, José Alberto De Schutter, Emiliano Lloret, L. Mosso, Marcelo Orlando, Juan Salomón, Susana Elsa |
| title_sort |
Bacteriemias por Pseudomonas Aeruginosa |
| title_short |
Bacteriemias por Pseudomonas Aeruginosa |
| url |
https://bdigital.uncu.edu.ar/fichas.php?idobjeto=3841 |
| estado_str |
3 |
| building |
Biblioteca Digital |
| filtrotop_str |
Biblioteca Digital |
| collection |
Artículo de Revista |
| institution |
Sistema Integrado de Documentación |
| indexed_str |
2023-04-25 00:38 |
| _version_ |
1764120326372851712 |
